What we do in life, echoes in eternity... Nature has always been a source of inspiration for the human. From beautiful sights to dangerous creatures nature offers a great diversity of interesting things and phenomena we want to learn about and explore. One can easily state that nature, together with the aspiration in life and development, is the driving force of science. What we see in nature is what gives us the questions. With this in mind it is interesting to mention that chemistry can explain very much of what happens in nature as life itself basically is chemistry in its purest form. In other words, chemistry, as all other sciences, derives from nature.
(A new approach towards the synthesis of Transtaganolides/Basiliolides C-19 Terpenolides from Thapsia with SERCA-inhibiting Activity)[1]
O čudesnoj biljci Thapsia GarganicaSmrtonosna mrkva ili Thapsia, commonly known as the deadly carrots! The ancient Greeks called the thapsia garganica plant "deadly carrot," because their camels would eat it and quickly die. The Roman emperor Nero mixed it with frankincense to treat bruises. Until the early 20th century it was used in a plaster to treat rheumatism—the side effects, however, were barely worth the cure.[2] Antireumatično: tapsigargin[3]
The chemical compound thapsigargin has been isolated from Thapsia garganica. A synthetic prodrug of thapsigargin called "G-202" is in preliminary clinical trials for cancer treatment.[5] The active constituent kills tumor cells by destroying their calcium balance. A biotech company called GenSpera, Inc. in San Antonio, TX is studying methods of delivering thapsigargin directly to cancer cells, avoiding damage to other cells in the body of the patient…. and six of the ten transmembrane helices exhibit large-scale rearrangements…
ATPase has 10 transmembrane α- helices, of which four form transmembrane Ca 2+ -binding sites or cavities!!!
Schematic models of dsDNA packaging in viruses: (a) helix Modelling of icosahedral viruses
[4]
Schematic models of dsDNA packaging in viruses: (a) helix at a spherical surface, (b) spool, (c) toroid, and (d) folded toroid. In (a) and (b), the individual DNA strands are shown (green), whereas in (c) and (d) the surface of the toroid (red) represents the envelop the close-packed DNA strands as illustrated in panel (c). (For interpretation of the references to colour in this figure legend, the reader is referred to the web version of this article…
/posljednji, yin-yang model!!!)
[1]
http://lup.lub.lu.se/luur/download?func=downloadFile&recordOId=2204317&fileOId=2204323
[2]
http://gizmodo.com/genspera/[3]
supa.pharmacy.bg.ac.rs/assets/4365[4]
http://www.sciencedirect.com/science/article/pii/S1359029407001483